- 1922
-
Established as the 15th junior high school in Osaka Prefecture
- 1948
- Renamed “Osaka Prefectural Sumiyoshi High School”
- 1990
- Established an International Cultural Studies Course
- 2002
- Marked its 80th anniversary
- 2005
- Reorganized as an "International and Science High School"
- 2007
- Designated as a Super Science High School (SSH) by Ministry of Education, Culture, Sports, Science and Technology (5-year program)
- 2008
- Granted membership in the UNESCO Associated School Program
- 2009
- Became a sister school with Zhongshan Girls" Senior High School in Taiwan.
- 2011
- Designated as an English Frontier High School (EFHS) by Osaka Prefectural Board of Education (3-year program)
- 2012
- Re-designated as a Super Science High School (SSH) by Ministry of Education, Culture, Sports, Science and Technology (5-year program)
- 2015
- Designated as an English Proficiency Training Program School by Osaka Prefectural Board of Education (3-year program)
- 2018
- Re-designated as a Super Science High School (SSH) by Ministry of Education, Culture, Sports, Science and Technology (5-year program)
- 2022
- Marked its 100th Anniversary